Reversal of Fillers with Hyalase (Hyaluronidase)

Hyaluronidase is an enzyme that breaks down the Hyaluronic Acid contained in most dermal fillers. It can be effectively used to quickly dissolve HA (Hyaluronic Acid) fillers, in the following situations:

Adverse vascular event/vascular occlusion, that is, inadvertent injection of dermal filler in a blood vessel (artery or vein), leading to a blockage to the blood flow to the skin. 

The incidence of impending necrosis following dermal filler treatment has been estimated at 0.001 percent (1 in 100,000 cases).

Hyaluronidase should be administered as soon as this complication occurs (within 4 hours). There is strong evidence that tissue necrosis can be prevented or reduced in severity if treatment is administered within 48 hours.

Unsatisfactory cosmetic outcome (over-correction, asymmetry)

Overcorrection or misplacement of HA filler can be successfully treated with hyaluronidase, although this is often caused by poor injection technique or poor choice of product for a particular indication.

Delayed onset nodules

 Lumps or nodules that appear several months after the initial treatment might be amenable with hyaluronidase.

Tyndall effect

The Tyndall effect refers to the scattering of light that may be seen in some patients after injection of HA resulting in a bluish hue of the skin and most commonly seen in the under-eye area. The problem can be resolved using hyaluronidase.

Reversal of Fillers with Hyalase (Hyaluronidase)

Hyaluronidase is an enzyme that breaks down the Hyaluronic Acid contained in most dermal fillers. It can be effectively used to quickly dissolve HA (Hyaluronic Acid) fillers, in the following situations:

Adverse vascular event/vascular occlusion, that is, inadvertent injection of dermal filler in a blood vessel (artery or vein), leading to a blockage to the blood flow to the skin. 

The incidence of impending necrosis following dermal filler treatment has been estimated at 0.001 percent (1 in 100,000 cases).

Hyaluronidase should be administered as soon as this complication occurs (within 4 hours). There is strong evidence that tissue necrosis can be prevented or reduced in severity if treatment is administered within 48 hours.

Unsatisfactory cosmetic outcome (over-correction, asymmetry)

Overcorrection or misplacement of HA filler can be successfully treated with hyaluronidase, although this is often caused by poor injection technique or poor choice of product for a particular indication.

Delayed onset nodules

 Lumps or nodules that appear several months after the initial treatment might be amenable with hyaluronidase.

Tyndall effect

The Tyndall effect refers to the scattering of light that may be seen in some patients after injection of HA resulting in a bluish hue of the skin and most commonly seen in the under-eye area. The problem can be resolved using hyaluronidase.